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Publications and presentations by Floyd Taub, M.D.

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Most Recent Major Presentation on Taurox™

Publications (Papers):

  1. Routenberg A, Taub FE.  Hippocampus and superior colliculus: congruent EEG activity demonstrated by a simple measure.  Behav. Biol., 1973; 8: 80.
  2. Taub F and Johnson TJ.  The mechanism of polyribosome disaggregation in brain tissue by phenylalanine.  Biochem. J., 1975; 151: 173-180.
  3. DeLeo JM, Taub F, Thompson B.  Computer analysis of autoradiographic images of recombinant DNA colonies. Division of Computer Research and Technology Annual Report, 1981; 2:42-43.
  4. Taub FE and Thompson EB.  An improved method for preparing large arrays of bacterial colonies containing plasmids for hybridization:  in situ purification and stable binding of DNA on paper filters.  Anal. Biochem., 1982; 126: 222-230.
  5. Taub FE, DeLeo JM and Thompson EB.  Sequential comparative hybridiza­tions analyzed by computerized image processing can identify and quantitate regulated RNAs.  DNA, 1983; 2: 309-327.
  6. DeLeo JM, Taub F, Thompson B. Computer analysis of autoradiographic images of recombinant DNA colonies. Division of Computer Research and Technology Annual Report, 1983; 2:44-45.
  7. Taub FE. Class II antigen expression in autoimmune disease. Lancet, 1984; 84:561.
  8. Ginsberg-Fellner F, ME Witt, B Fedun, F Taub, MJ Dobersen, RC McEvoy, LZ Cooper, AL Notkins, P Rubinstein. Diabetes mellitus and autoimmunity in patients with the congenital rubella syndrome. Review of Infectious Diseases, 1985; 7 (Suppl. 1):S170-S176.
  9. Ginsberg-Fellner F, ME Witt, S Yagihashi, MJ Dobersen, F Taub, B Fedun, RC McEvoy, SH Roman, TF Davies, LZ Cooper, P Rubinstein, AL Notkins. Congenital rubella syndrome as a model for type I (insulin-dependent) diabetes mellitus: increased prevalence of islet cell antibodies. Diabetologia, 1984; 27:87-89.
  10. Ginsberg-Fellner F, ME Witt, S Yagihashi, MJ Dobersen, F Taub, B Fedun, RC McEvoy, SH Roman, TF Davies, LZ Cooper, P Rubinstein, AL Notkins. Congenital rubella syndrome as a model for type I (insulin-dependent) diabetes mellitus: increased prevalence of islet cell antibodies. Diabetologia, 1984; 27:87-89.
  11. Sutherland DER, R Sibley, X-Z Xu, A Michael, S Srikanta, F Taub, J Najarian, FC Goetz (intro. by JH Oppenheimer). Twin-to-twin pancreas transplantation: reversal and reenactment of the pathogenesis of type I diabetes. Transactions of the Association of American Physicians, 1984; 97:80-87.
  12. Garzelli C; Taub FE; Scharff JE; Prabhakar BS, Ginsberg‑Fellner F; Notkins AL.  Epstein‑Barr virus‑transformed lymphocytes produce monoclonal autoantibodies that react with antigens in multiple organs.  J Virol 1984; 52: 722-5.
  13. Taub, FE, Satoh, J, Garzelli, C, Essani, K and Notkins, AL.  Human monoclonal autoantibodies reactive with multiple organs.  Human Hybridomas and Monoclonal Antibodies (eds. E.G. Engleman, et al.) Plenum Publishing Corporation, New York, 1985.
  14. Eskinazi DP, J Satoh, CJ Wheeler, ET Harrison Jr., FE Taub. Detection of antibodies reacting with live rat insulinoma cells in the serum of patients with insulin-dependent diabetes mellitus (IDDM) by an 125I-protein A microassay.  Immunology Letters, 1985; 10:353-354.
  15. Garzelli C, FE Taub, MC Jenkins, DW Drell, F Ginsberg-Fellner, AL Notkins. Human monoclonal autoantibodies that react with both pancreatic islets and thyroid. Journal of Clinical Investigation, 1986; 77:1627-1631.
  16. Taub FE. DNA diagnostic techniques in microbiology. SIM News, 1986; 36:6-7.
  17. Hakim FT, AD Steinberg, P Smathers, KS Brown, F Taub, JJ Oppenheim. Hereditary joint disorder in progressive ankylosis (ank/ank) mice: III. Involvement of the immune system. Doctoral dissertation, University of Maryland, 1986.
  18. Taub FE, SL Grillo, CM Bruns, N Moore, ME Mosher. The use of DNA probes to diagnose viral infections. Developments in Industrial Microbiology, 1988; 29 (Journal of Industrial Microbiology, Suppl. No. 3):119-129.
  19. Taub F. In situ hybridization in surgical pathology. Advances in Surgical Pathology lecture at George Washington University, Washington, DC. May 7, 1988.
  20. McClintock JT, Thaker SR, Mosher M, Jones D, Forman M, Charache P, Wright K, Keiser J, Taub FE.  Comparison of in situ hybridization and monoclonal antibodies for early detection of cytomegalovirus in cell culture.  J Clin Microbiol, 1989; 27: 1554-9.
  21. Higgs TW, Moore NJ, Badawi DY and Taub FE.  Type-specific HPV detection in formalin-fixed, paraffin-embedded tissue sections using non-radioactive DNA probes.  Laboratory Investigation, 1990; 63: 557-567.
  22. Schoone GJ, van Eys GJ, Ligthart GS, Taub FE, Zaal J, Mebrahtu Y, Laywer P.  Detection and identification of Leishmania parasites by in situ hybridization with total and recombinant DNA probes.  Exp Parasitol, 1991; 73: 345-53.
  23. McClintock JT, Mosher M, Thaker SR, Wacker WK, Jones D, Forman M, Adler SP, Charache P, Taub FE.  Culture confirmation of cytomegalovirus and herpes simplex virus by direct enzyme‑labeled DNA probes and in situ hybridization.  J Virol Methods, 1991; 35: 81-91.
  24. McCarthy M, Resnick L, Taub F, Stewart RV, Dix RD.  Infection of human neural cell aggregate cultures with a clinical isolate of cytomegalovirus.  J Neuropathol Exp Neurol, 1991; 50: 441-50.
  25. McClintock JT, Chan IJ, Thaker SR, Katial A, Taub FE, Aotaki‑Keen AE, Hjelmeland LM.   Detection of c‑sis proto‑oncogene transcripts by direct enzyme‑labeled cDNA probes and in situ hybridization.  In Vitro Cell Dev Biol., 1992; 28: 102-8.
  26. McClintock JT, I-J Chan, SR Thaker, A Katial, FE Taub, AE Aotaki-Keen, LM Hjelmeland. The detection of RNA transcripts by non-radioactive in situ hybridization. In preparation.
  27. McClintock JT; Chan IJ; Taub FE; Friedman‑Kien AE, Resnick L.  Rapid detection of Epstein‑Barr virus DNA in clinical samples of oral hairy leukoplakia with HRP‑labeled DNA probes and in situ hybridization.  J Virol Methods, 33, 155-64 (1991.)
  28. Badawi DY, L Etienne, TW Higgs, NJ Moore, FE Taub. Comparison study of non-radioactive probes for the rapid detection of HPV in histological sections. In preparation.
  29. Lazar JG, Taub FE, Kessler C. A highly sensitive method for detecting peroxidase in situ hybridization or immunohistochemical assays. Nonradioactive Labeling and Detection of Biomolecules Berlin: Springer-Verlag; 1992: 135-142.
  30. Dunn T, Wormsley S, Taub FE, and Pontzer CH. Increased T cell cytotoxicity by Beta LTTM-induced upregulation of TNF-alpha. International Journal of Immunopharmacology. 2000: 22, 213-227.

Publications (Abstracts):

  1. Sutherland DER, R Sibley, P Chinn, A Michael, S Srikanta, F Taub, J Najarian, FC Goetz (intr. by JH Oppenheimer). Twin-to-twin pancreas transplantation (TX): reversal and reenactment of the pathogenesis of type I diabetes. Clinical Research, 1984; 32:561A.
  2. Taub FE, J Scharff. Assay of islet cell antibodies (ICA), a more sensitive method. Diabetes, 1984; 33 (Suppl. 1):63A.
  3. Yoon JW, JS Scharff, CJ Bachurski, TH Lee, FE Taub. Antibody to islet cell antigens from patients with Vacor induced insulin-dependent diabetes mellitus. Diabetes, 1984; 33 (Suppl. 1):161A.
  4. Katial A, K Roshto, T Higgs, F Taub. Peroxidase labeled nucleic acid probes. Poster presented to the American Society of Biological Chemists, Washington, DC, 1986.
  5. Taub F, H Rutherford. Processing images of radioautographs to analyze nucleic acid hybridizations: a computerized method to study multiple gene expression.  Poster presented to the American Society of Biolgoical Chemists, Washington, DC 1986.
  6. Katial A, K Roshto, E Cantin, F Taub. Detection of herpes virus using peroxidase labeled nucleic acid probes. Poster presented at the 1st Annual ASM Conference on Biotechnology, Washington, DC, 1986.
  7. Roshto K, T Higgs, A Shaikh, J Saba, F Taub. Background reduction in filter hybridizations. The use of direct nucleic acid horseradish peroxidase conjugates. Poster presented to the American Society of Biological Chemists, 1987.
  8. Grillo S, M Mosher, P Charles, S Henry, F Taub. DNA/DNA in situ hybridization with enzyme linked probes.  Poster presented to the American Society of Biological Chemists, 1987.
  9. Grillo SL, CM Bruns, ME Mosher, FE Taub. The use of direct DNA-peroxidase conjugates for rapid, non-radioactive detection of HPV sequences by in situ hybridization. Poster presented at the 6th International Papillomavirus Workshop, Washington, DC, 1987. Published in Abstracts of Papers Presented at the Sixth International Papillomavirus Workshop, p.105.
  10. Mosher ME, SL Grillo, N Moore, A Maters, R Ambinder, FE Taub. Rapid detection of herpesviruses by in situ hybridization with enzyme-linked probes. Poster presented at the 12th International Herpesvirus Workshop, Philadelphia, PA, 1987.
  11. Mosher ME, SL Grillo, N Moore, A Maters, M Forman, R Ambinder, FE Taub. Rapid detection of virus-infected cells by in situ hybridization using DNA probes directly linked to active enzymes.  Poster presented at Gene Probe Technology II: 1987 American Association for Clinical Chemistry San Diego Conference.
  12. Mosher M, A Maters, D Jones, M Forman, S Grillo, F Taub. Rapid detection of cytomegalovirus-infected cells by in situ hybridization with enzyme-linked DNA probes. Abstracts of the Annual Meeting of the American Society for Microbiology, 1988, p.320.
  13. Bruns CM, C Cardozo, CR Ceccarelli, L Corey, JM Douglas, SL Grillo, A Langenberg, J Saba, FE Taub. Rapid in situ hybridization to HPV DNA sequences in cervical smears using direct enzyme-labeled DNA probes. Poster presented at the 7th International Papillomavirus Workshop, Sophia Antipolis, France, 1988. Published in Seventh International Papillomavirus Workshop, p.30.
  14. Taub, F. In situ hybridization in surgical pathology. Talk given at George Washington University, Washington, D.C. on May 7, 1988, as part of the series, "Advances in Surgical Pathology."
  15. Higgs T, N Moore, G Gamerman, C Bruns, D Badawi, F Taub. Highly sensitive, rapid, and specific detection of HPV types 6/11 and 16/18 in formalin-fixed paraffin-embedded sections using directly conjugated HRP-labeled DNA probes.  Poster presented at the 8th International Papillomavirus Workshop, Taos, NM, 1989. Published in Journal of Cellular Biochemistry, Suppl.13C, 1989, p.187.
  16. Bruns CM, CR Ceccarelli, J Summerville, T Higgs, FE Taub. Type-specific HPV detection in Pap smears by in situ hybridization with enzyme-DNA conjugates. Poster presented at the 8th International Papillomavirus Workshop, Taos, NM, 1989. Published in Journal of Cellular Biochemistry, Suppl.13C, 1989, p.182.
  17. McClintock JT, A Friedman-Kien, F Taub. Direct detection of Epstein-Barr virus in tongue tissue smears from individuals with suspected hairy leukoplakia.  Poster presented to the American Society for Microbiology, New Orleans, LA, 1989. Published in Abstracts of the 89th Annual Meeting of the American Society for Microbiology 1989, p.373.
  18. Wacker WK, JT McClintock, S Strohofer, S Kahn, RP Baughman, FE Taub. Direct detection of cytomegalovirus in bronchoalveolar lavages using HRP-labeled DNA probes and in situ hybridization.  Poster presented to the American Society for Microbiology, New Orleans, LA, 1989. Published in Abstracts of the 89th Annual Meeting of the American Society for Microbiology 1989, p.373.
  19. Badawi D, M Garcia, T Higgs, C King, S Yang, F Taub. Direct-labeled DNA probes for rapid viral diagnosis. Poster presented to the Society for Pediatric Pathology, Aspen, CO, 1989.
  20. King PC, WK Wacker, RP Robinson, J Colandrea, R Robinson, FE Taub. Direct detection of CMV in bronchoalveolar lavage specimens using in situ hybridization. Poster presented to the Pulmonary Pathology conference sponsored by the Washington Hospital Center, Washington, DC, 1989.
  21. King C, W Wacker, R Baughman, J Colandrea, R Robinson, B Weinstein, F Taub. CMV detection in cytologic and histologic specimens, using direct-labeled DNA probes and in situ hybridization. Poster presented at The International Academy of Pathology, Boston, MA, 1990. Published in Modern Pathology 3:52A, 1990.
  22. King C, W Wacker, R Baughman, J Colandrea, R Robinson, B Weinstein, F Taub. CMV detection in cytologic and histologic specimens, using direct-labeled DNA probes and in situ hybridization. Poster presented at The International Academy of Pathology, Boston, MA, 1990. Published in Modern Pathology 3:52A, 1990.
  23. Taub F, C King, T Higgs. Viral identification in situ with direct-labeled DNA probes. Poster presented at the UCLA symposium "Animal Models of Human Viral Diseases: Relevance to Developmental Therapeutics," Keystone, CO, 1990.
  24. Taub F, S Thaker, H Salim, M Wesoloski, D Badawi. "Single copy detection" of HPV16 in SiHa cells with direct HRP-DNA probes. Poster presented at Papillomavirus Workshop 1990, Heidelberg, Germany, 1990.
  25. Taub F, JS Park, D Badawi, K Shah. DNA-HRP probes reveal different morphological patterns of HPV distribution in benign and malignant neoplastic lesions. Poster presented at Papillomavirus Workshop 1990, Heidelberg, Germany, 1990.
  26. Miller W, Caplan S, Shustik C, McQuillan A, Sicilia F, Batist G, Mayerson S, Taub F. Toxicity and Biological Effects of Beta-alethine - Report of the First Phase I/II Study. Poster presented at VII International  Multiple Myeloma Workshop 1999, Stockholm, Sweden 1999.

Publications concerning Beta-alethine:

  1. Taub, F. Beta-alethine (Beta LT™): A Low Molecular Weight Cytokine Inducer with Anti-Cancer Properties and Low Toxicity in Mice and Man? Review of Data to Date. Poster presented at Cancer Immunosurveillance 1999 - Cancer Research Institute, New York, New York 1999.
  2. Taub F, Mayerson S, McQuillan A, Caplan S, Shustik C, Miller W. Phase I/II Evaluation of Beta LT™ as an antilymphoma agent and enhancer of DTH in lymphoma patients. Poster presented at The International Conference on Molecular Targets and Cancer Therapeutics, Washington, D.C. 1999.
  3. Miller WH, Caplan S, Shustik C, McQuillan A, Sicilia F, Mayerson S, Taub F. Beta-alethine Immunomodulation in Follicular B Cell Lymphoma and Multiple Myeloma: Initial Phase I/II Results. Submitted. Blood Supplement (Part II), November 15, 1999.
  4. W.H. Miller, Jr., S. Caplan, C., Shustik, A. McQuillan, F. Sicilia, S. Mayerson and F. Taub. Beta-alethine: TNF alpha, Antitumor Effects and Delayed Type Hypersensitivity in Follicular B-Cell Lymphoma. Oral presentation at the ISH 2000 (28th International Congress) Toronto, Ontario, August 2000.
  5. F. Taub. Review of Beta LT immunomodulation in lab studies and patients with follicular B cell lymphoma: Initial phase I/II results.  Presented at the Comprehensive Cancer Care 2000, Arlington, VA, June 2000.
  6. F. Taub, K. Manos, S. Mayerson. A review of animal models and human clinical trial data supportive of beta-alethine (BT) immune therapy for minimal residual disease (MRD). Presented at the 15th Annual Scientific Meeting of the Society for Biological Therapy, Seattle, WA October 2000.
  7. W.H. Miller, Jr., S. Caplan, C., Shustik, A. McQuillan, F. Sicilia, S. Mayerson and F. Taub. T cells exhibit increased TNF alpha and delayed type hypersensitivity responses are restored in patients with B cell malignancies following administration of beta-alethine. Presented at the American Association for Cancer Research, 11th NCI-EORTC-AACR Symposium Amsterdam, The Netherlands, November 2000.
  8. C.H. Pontzer and F. Taub. Reducing toxicity of recombinant biomolecules through engineering. Presented at the Cambridge Healthtech Institute Recombinant Therapeutics: Antibodies and Biomolecules Conference, Baltimore, MD, June 2001.

Patents:

  1. Taub F. Assay for Nucleic Acid Sequences, Particularly Genetic Lesions, Using Interactive Labels.
  2. Taub F. Bifunctional DNA-Protein Conjugating Agent.
  3. Taub F, Higgs TW, Roshto K. Macromolecular Conjugate.
  4. Higgs TW, Taub F. A Highly Sensitive Method for Detecting Peroxidase.
  5. Taub FE, Lazar J. Macromolecular Conjugate Made by  (confidential).

Scientific Presentations, Conferences and Public Relations in 2003 & 2004 for Taurox™

Sample Presentations by Dr. Floyd Taub:

Listing of Scientific Research concerning Taurox

  1. Taurox SB™ -- Molecular Activity, Safety, and Efficacy, Taub, F.E.
  2. Data on Fatigue, Allergies and Hepatitis from Structured Case Histories and Clinical Outcome Trials of Taurox™
  3. Taurox™ Clinical Trials Protocol
  4. In Vitro Cell Culture In Media Containing Beta-Alanyl-Taurine or Carbobenzoxy Beta-Alanyl-Taurine, Knight, G. D., Scanlen, T. J., University of New Mexico, Issued U.S. Patent Number 6,323,025 B1, November 27, 2001
  5. In Vitro Cell Culture In Media Containing Beta-Alanyl-Taurine or Carbobenzoxy Beta-Alanyl-Taurine, Knight, G. D., Scanlen, T. J., University of New Mexico, Issued U.S. Patent Number 6,096,536, August 1, 2000
  6. The Anticancer Properties of Taurox SB may be Mediated by an Immunostimulatory Mechanism, Dunn, T.M., Wormsley, S., Taub, F.E., and Pontzer, C.H. Abstract presented at the American Society for Pharmacology and Experimental Therapeutics.
  7. The Immunostimulatory Effects of Taurox SB™, Dunn, T. M., Taub, F. E., Pontzer, C H., Department of Cell Biology and Molecular Genetics, University of Maryland, Submitted for publication 2001
  8. Thesis on the Immunostimulatory Effects of Taurox SB™, Dunn, T. M., Department of Pharmacology and Experimental Therapeutics, University of Maryland at Baltimore School of Medicine, 2000
  9. Therapeutic Use of Vitalethine Modulators in Neoplasis, Knight, G. D., Scanlen, T. J., University of New Mexico, Issued U.S. Patent Number 5,578,313, November 26, 1996
  10. Therapeutic Use of Vitalethine Modulators in Neoplasia, Knight, G. D., Scanlen, T. J., University of New Mexico, Issued U.S. Patent Number 5,370,868, December 4, 1994
  11. Vitalethine Modulates Erythropoisis and Neoplasia, Knight, G. D., Laubscher, K. H., Fore, M. L., Clark… Scanlen, T. J., Cancer Research, 1994; 54(21): 5623-35

Taurox SB™ Monograph and Toxicology Documents Available

  1. Addendum to Toxicology Monograph on Taurox SB™, Rice, S. A., April 1, 2002 (Confidential)
  2. Taurox SB Review Of Dr. Susan Rice’s Toxicology Monograph And Response To 4 November 2001 MRC Meeting Report Questions, Hood, R. D., March 29, 2002 (Confidential).
  3. Comparison of Toxicity Risks of Five Common Homeopathic Drugs and Taurox SB, Foxman, E. L., October 23, 2001 (Confidential)
  4. Proving Report – Taurox SB™, Riley, D., Integrative Medicine Institute, 2001 (Confidential)
  5. Toxicology Monograph on Taurox SB™, Rice, S. A., September 13, 2001 (Confidential)
  6. Taurox Monograph Submissions, May 2001 and September 2001 (Confidential)

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